Mississippi

Mississippi legalized medical cannabis in February 2022 when Governor Tate Reeves signed Senate Bill 2095, the Mississippi Medical Cannabis Act, following the state Supreme Court's 2021 invalidation of Initiative 65 on procedural grounds. The Mississippi Medical Cannabis Program, managed by the Mississippi State Department of Health, has grown rapidly since retail sales began in early 2023. As of late 2025, the program serves over 66,000 active patients through approximately 175 to 190 licensed dispensaries, with 57 cultivators, 60 micro-cultivators, and 18 processors also licensed. Cannabis tax revenue reached $2.18 million in 2025, with an additional $9 million in state sales tax collected. Qualifying conditions include cancer, epilepsy, chronic pain, PTSD, spasticity, and Parkinson's disease. Patients may purchase up to 3 ounces per month.