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Adult-Use & Medical — LegalNorth America

Missouri

Missouri voters approved Constitutional Amendment 3 in November 2022 with approximately 53% support, legalizing adult-use cannabis for adults 21 and older. Retail adult-use sales began on February 3, 2023, and the market has grown rapidly. Through March 2026, combined medical and adult-use sales reached $131 million in a single month, with recreational purchases setting new monthly records. Cumulative industry revenue is approaching $5 billion since adult-use legalization. The Division of Cannabis Regulation (DCR) within the Department of Health and Senior Services oversees both programs. Adults may possess up to 3 ounces and purchase up to 3 ounces per transaction. The medical program, originally established in 2018 via Amendment 2, continues alongside adult-use with over 120,000 registered patients. Microbusiness licenses remain a key mechanism for increasing market diversity and equity.

Ask the Expert about Missouri
Regulator
Division of Cannabis Regulation
Key Legislation
Mo. Const. Art. XIV
Year Legalized
2018 (medical); 2022 (adult-use)
Program Size
~120,000 medical patients; adult-use ...

Key Facts

  • Adult-use sales launched February 3, 2023, following voter approval of Amendment 3 in November 2022
  • March 2026 sales hit $131 million, with recreational purchases setting a new monthly record
  • Cumulative cannabis industry revenue approaching $5 billion since adult-use launch
  • Adults 21+ may possess and purchase up to 3 ounces of cannabis
  • Microbusiness licensing program designed to promote market diversity and equity

Key Legislation

Mo. Const. Art. XIV (Amendment 2, 2018; Amendment 3, 2022); Mo. Rev. Stat. §§195.800–195.826

Regulatory Body

Division of Cannabis Regulation (DCR), Missouri Department of Health and Senior Services

Country Info
ISO Code
US
Region
North America
Tier
Tier 1 — Active Program
Status
Adult-Use & Medical — Legal
Sources
Missouri Division of Cannabis RegulationMissouri Cannabis Sales Data & ReportsMarijuana Policy Project — Missouri
Disclaimer: This information is for general reference only and does not constitute legal advice. Cannabis regulations change frequently. Always verify with official sources and local legal counsel before making compliance decisions.