Missouri voters approved Constitutional Amendment 3 in November 2022 with approximately 53% support, legalizing adult-use cannabis for adults 21 and older. Retail adult-use sales began on February 3, 2023, and the market has grown rapidly. Through March 2026, combined medical and adult-use sales reached $131 million in a single month, with recreational purchases setting new monthly records. Cumulative industry revenue is approaching $5 billion since adult-use legalization. The Division of Cannabis Regulation (DCR) within the Department of Health and Senior Services oversees both programs. Adults may possess up to 3 ounces and purchase up to 3 ounces per transaction. The medical program, originally established in 2018 via Amendment 2, continues alongside adult-use with over 120,000 registered patients. Microbusiness licenses remain a key mechanism for increasing market diversity and equity.
Ask the Expert about MissouriMo. Const. Art. XIV (Amendment 2, 2018; Amendment 3, 2022); Mo. Rev. Stat. §§195.800–195.826
Division of Cannabis Regulation (DCR), Missouri Department of Health and Senior Services