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Medical — LegalNorth America

Pennsylvania

Pennsylvania enacted the Medical Marijuana Act (Act 16) in April 2016, establishing one of the most expansive medical cannabis programs in the northeastern United States. The Pennsylvania Department of Health oversees the program, which has grown to serve over 439,000 active patients through approximately 185 licensed dispensaries. Cumulative retail sales have surpassed $8.5 billion, making it the sixth-largest cannabis retail market in the country despite being medical-only. The program covers 24 qualifying conditions including anxiety, opioid use disorder, chronic pain, and cancer. Pennsylvania permits up to 25 grower-processors and 50 dispensary permits. The state has seen strong bipartisan interest in adult-use legislation but no measure has passed as of 2026. Home cultivation remains prohibited for patients.

Ask the Expert about Pennsylvania
Regulator
Office of Medical Marijuana, Pennsylvania Department of Health
Key Legislation
35 Pa. Stat. §10231.101 et seq.
Year Legalized
2016
Program Size
~439,000 active patients

Key Facts

  • Sixth-largest cannabis retail market in the U.S. with over $8.5 billion in cumulative sales
  • 185 operational dispensaries serving patients across the commonwealth
  • Program-to-date patient registrations surpassed 1 million by November 2025
  • 24 qualifying conditions including anxiety and opioid use disorder
  • Home cultivation is not permitted; patients must purchase from licensed dispensaries

Key Legislation

35 Pa. Stat. §10231.101 et seq. (Medical Marijuana Act, Act 16 of 2016)

Regulatory Body

Office of Medical Marijuana, Pennsylvania Department of Health

Country Info
ISO Code
US
Region
North America
Tier
Tier 2 — Emerging
Status
Medical — Legal
Sources
PA Department of Health — Medical Marijuana ProgramMedical Marijuana Act (Act 16 of 2016)
Disclaimer: This information is for general reference only and does not constitute legal advice. Cannabis regulations change frequently. Always verify with official sources and local legal counsel before making compliance decisions.